Validation of human microRNA target pathways enables evaluation of target prediction tools
نویسندگان
چکیده
منابع مشابه
Common features of microRNA target prediction tools
The human genome encodes for over 1800 microRNAs (miRNAs), which are short non-coding RNA molecules that function to regulate gene expression post-transcriptionally. Due to the potential for one miRNA to target multiple gene transcripts, miRNAs are recognized as a major mechanism to regulate gene expression and mRNA translation. Computational prediction of miRNA targets is a critical initial st...
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MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs of 20-24 nucleotides that regulate flow of genetic information by controlling translation or stability of mRNAs in higher eukaryotes. The miRNAs are reported to be involved in many biological processes, and the discovery of miRNAs has been provided great impacts on computational biology as well as traditional biology. Most miRNA-a...
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Introduction: The prediction of microRNAs related to target genes using bioinformatics tools saves time and costs of the experimental analyses. In the present study, the prediction of microRNA target genes relevant to Alzheimer’s Diseases (AD) were compared with the experimentally reported data using different bioinformatics tools. Method: A total of 41 microRNAs associated with 21 essential ge...
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Introduction: The prediction of microRNAs related to target genes using bioinformatics tools saves time and costs of the experimental analyses. In the present study, the prediction of microRNA target genes relevant to Alzheimer’s Diseases (AD) were compared with the experimentally reported data using different bioinformatics tools. Method: A total of 41 microRNAs associated with 21 essential ge...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2020
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkaa1161